ISOLDE: Bringing structural biology to life


Live atomic symmetry

A defining feature of a crystallographic model is that it does not exist in isolation, but as part of a symmetric lattice. Crystal contacts (whether or not they are biologically relevant) are often important during refinement. ISOLDE's default visualisation mode represents crystallographically-related copies of the asymmetric unit as darker "ghosts" of the main model, updating with every coordinate change.


(Note: symmetry atoms cannot be directly manipulated, and do not currently take part in simulations. This is covered in more detail in the documentation.)

ISOLDE is developed and maintained by Tristan Croll in the lab of Randy Read at the Cambridge Institute for Medical Research and supported by Prof. Read's Wellcome Trust Principal Research Fellowship 209407/Z/17/Z. Development and testing has been aided by the generous donation of a GTX Titan Xp GPU by NVIDIA Corporation.

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